Stand-Up

"He completely changed my life," Apatow says of his mentor. It's Garry Shandling's Book, which Apatow edited, explores the insecurities and personal trauma that Shandling turned into comedy.

The Australian comedian publicly called it quits in her breakout special, Nanette, last year. That only got more people to pay attention. She now returns with a new tour, Douglas.

For centuries, people have turned to jesters for relief from the miseries of life. As it turns out, some stand-up performers turn pain and rage into their own coping and catharsis.